We do not recommend upgrades on computers older than 2011.
On computers with an third-party upgraded SSD, be aware that TRIM will stop working which may degrade performance.
Be aware that some programs may stop working, like old versions of Office and EndNote. Getting a new version of EndNote involves a cost. Office is free (not really, but the university already payed for it).
But other than that, go ahead. Most things work better. If you have any questions contact email@example.com.